Key Focus

  • Abhinav Nellore is an assistant professor of biomedical engineering and surgery and Reid Thompson is an assistant professor of radiation medicine, both also at Oregon Health & Science University. This was first published by The Conversation. "Your genes could determine whether the coronavirus puts you in the hospital - and we're starting to unravel which ones matter"
  • In theory, we could repeat this analysis to better understand the genetic risks of many viruses that currently or could potentially infect humans.
    Now read:Treating a typical coronavirus infection is four times the cost of a case of the flu
    Austin Nguyen is a Ph.D. candidate in computational biology and biomedical engineering at Oregon Health & Science University in Portland.


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High Level Topics

  • HLA
  • CORONAVIRUS
  • SARS-COV-2
  • COVID-19
  • High Level Abstractions

  • HLA(3, 0 Order)
  • ( HLA )(3, 0 Order)  top
  • CORONAVIRUS(5, 0 Order)
  • ( CORONAVIRUS )(5, 0 Order)  top
  • ( CORONAVIRUS, SCIENCE_UNIVERSITY )(2, 1st Order)  top
  • ( CORONAVIRUS, REID_THOMPSON )(1, 1st Order)  top
  • ( CORONAVIRUS, OREGON_HEALTH )(2, 1st Order)  top
  • ( CORONAVIRUS, IMMUNE )(2, 1st Order)  top
  • ( CORONAVIRUS, HLA )(1, 1st Order)  top
  • ( CORONAVIRUS, COVID-19 )(1, 1st Order)  top
  • ( CORONAVIRUS, COMPUTER )(2, 1st Order)  top
  • ( CORONAVIRUS, BIOMEDICAL )(2, 1st Order)  top
  • ( CORONAVIRUS, ALLELES )(1, 1st Order)  top
  • ( CORONAVIRUS, VIRUS )(1, 1st Order)  top
  • ( CORONAVIRUS, UNDETECTABLE )(1, 1st Order)  top
  • ( CORONAVIRUS, SARS-COV-2 )(1, 1st Order)  top
  • SARS-COV-2(1, 0 Order)
  • ( SARS-COV-2 )(1, 0 Order)  top
  • COVID-19(1, 0 Order)
  • ( COVID-19 )(1, 0 Order)  top
  • References

    • ( HLA )  top
    • (Read more)   topand we're starting to unravel which ones matter Published: May 5, 2020 at 1:56 p.m. ET By Austin Nguyen, Abhinav Nellore and Reid Thompson Differences in HLA genes may be a significant reason for huge differences in infections When some people become infected with the coronavirus, they only develop mild or undetectable cases of COVID-19
    • (Read more)   top... database. We then took that list and used existing computer algorithms to predict how well different versions of the anti-viral alarm system detected these coronavirus proteins. A model of an HLA protein (green and yellow) bound to a piece of a virus (orange and blue) - in this case, influenza
    • (Read more)   topCurrently, we know very little about the relationship between many other viruses and HLA type. In theory, we could repeat this analysis to better understand the genetic risks of many viruses that currently or could potentially infect humans. Now read:Treating a typical coronavirus...
    • ( CORONAVIRUS )  top
    • ( CORONAVIRUS, SCIENCE_UNIVERSITY )  top
    • (Read more)   top.D. candidate in computational biology and biomedical engineering at Oregon Health & Science University in Portland.
    • (Read more)   topAbhinav Nellore is an assistant professor of biomedical engineering and surgery and Reid Thompson is an assistant professor of radiation medicine, both also at Oregon Health & Science University. This was first published by The Conversation. "Your genes could determine whether the coronavirus puts you in the hospital - and we're starting to unravel which ones matter"
    • ( CORONAVIRUS, REID_THOMPSON )  top
    • (Read more)   topAbhinav Nellore is an assistant professor of biomedical engineering and surgery and Reid Thompson is an assistant professor of radiation medicine, both also at Oregon Health & Science University
    • ( CORONAVIRUS, OREGON_HEALTH )  top
    • (Read more)   top.D. candidate in computational biology and biomedical engineering at Oregon Health & Science University in Portland.
    • (Read more)   topAbhinav Nellore is an assistant professor of biomedical engineering and surgery and Reid Thompson is an assistant professor of radiation medicine, both also at Oregon Health & Science University. This was first published by The Conversation. "Your genes could determine whether the coronavirus puts you in the hospital - and we're starting to unravel which ones matter"
    • ( CORONAVIRUS, IMMUNE )  top
    • (Read more)   top
      To test this, we used computer models to analyze known genetic variation within the human immune system.
    • (Read more)   top
      To test whether different alleles of this alarm system could explain some of the range in immune responses to SARS-CoV-2, we first retrieved a list of all the proteins that make up the coronavirus from an online database.
      We then took that list and used existing computer algorithms to predict...
    • ( CORONAVIRUS, HLA )  top
    • (Read more)   top
      A model of an HLA protein (green and yellow) bound to a piece of a virus (orange and blue) - in this case, influenza
    • ( CORONAVIRUS, COVID-19 )  top
    • (Read more)   top
      When some people become infected with the coronavirus, they only develop mild or undetectable cases of COVID-19. Others suffer severe symptoms, fighting to breathe on a ventilator for weeks, if they survive at all.
      Despite a concerted global scientific effort, doctors still lack a clear picture of why this...
    • ( CORONAVIRUS, COMPUTER )  top
    • (Read more)   top
      To test this, we used computer models to analyze known genetic variation within the human immune system.
    • (Read more)   top
      We then took that list and used existing computer algorithms to predict how well different versions of the anti-viral alarm system detected these coronavirus proteins.
      A model of an HLA protein (green and yellow) bound to a piece of a virus (orange...
    • ( CORONAVIRUS, BIOMEDICAL )  top
    • (Read more)   top.D. candidate in computational biology and biomedical engineering at Oregon Health & Science University in Portland.
    • (Read more)   topAbhinav Nellore is an assistant professor of biomedical engineering and surgery and Reid Thompson is an assistant professor of radiation medicine, both also at Oregon Health & Science University
    • ( CORONAVIRUS, ALLELES )  top
    • (Read more)   topand some of these alleles are more sensitive to certain viruses or pathogens than others.
      To test whether different alleles of this alarm system could explain some of the range in immune responses to SARS-CoV-2, we first...
    • ( CORONAVIRUS, VIRUS )  top
    • (Read more)   top
      A model of an HLA protein (green and yellow) bound to a piece of a virus (orange and blue) - in this case, influenza
    • ( CORONAVIRUS, UNDETECTABLE )  top
    • (Read more)   top
      When some people become infected with the coronavirus, they only develop mild or undetectable cases of COVID-19. Others suffer severe symptoms, fighting to breathe on a ventilator for weeks, if they survive at all.
      Despite a concerted global scientific effort, doctors still lack a clear...
    • ( CORONAVIRUS, SARS-COV-2 )  top
    • (Read more)   top
      To test whether different alleles of this alarm system could explain some of the range in immune responses to SARS-CoV-2, we first retrieved a list of all the proteins that make up the coronavirus from an online database.
      We then took that list and used existing computer algorithms to predict how well different versions...
    • ( SARS-COV-2 )  top
    • (Read more)   top... of these alleles are more sensitive to certain viruses or pathogens than others. To test whether different alleles of this alarm system could explain some of the range in immune responses to SARS-CoV-2, we first retrieved a list of all the proteins that make up the coronavirus from an online database. We then took that list and used existing computer algorithms to predict how well different...
    • ( COVID-19 )  top
    • (Read more)   top ... Reid Thompson Differences in HLA genes may be a significant reason for huge differences in infections When some people become infected with the coronavirus, they only develop mild or undetectable cases of COVID-19. Others suffer severe symptoms, fighting to breathe on a ventilator for weeks, if they survive at all. Despite a concerted global scientific effort, doctors still lack a clear picture of why...