Logical Analysis Report

Key Focus

  • One is Roche.s drug, and the other is our drug, Kevzara. We worked very rapidly to design a trial. We worked closely with the FDA, collaborated with Barda [Biomedical Advanced Research and Development Authority], got help from Gov
  • SVB Leerink analyst Geoffrey Porges wrote in a note to investors.
    A day earlier, Regeneron (ticker: REGN) said it had started trials with its existing arthritis drug, Kevzara, which might prove useful in treating lung inflammation in Covid-19 patients, keeping them off ventilators and out of intensive care units.
    Barron.s spoke with Regeneron CEO Leonard Schleifer on Tuesday morning about the fight against Covid-19, how the company.s technology platform is speeding drug discovery, and how to think about the economics of treatments for pandemic diseases

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High Level Topics

  • DRUG
  • VIRUS
  • INFLAMMATION
  • COVID-19

    • High Level Abstractions

  • DRUG(6, 0 Order)
  • ( DRUG )(6, 0 Order)  top
  • ( DRUG, INFLAMMATION )(3, 1st Order)  top
  • ( DRUG, VIRUS )(1, 1st Order)  top
  • ( DRUG, KEVZARA )(2, 1st Order)  top
  • ( DRUG, EBOLA )(1, 1st Order)  top
  • ( DRUG, ANTIBODIES )(2, 1st Order)  top
  • ( DRUG, VIRUS-NEUTRALIZING )(1, 1st Order)  top
  • ( DRUG, VACCINE )(1, 1st Order)  top
  • ( DRUG, ROCHE_HOLDING )(1, 1st Order)  top
  • ( DRUG, REMDESIVIR )(1, 1st Order)  top
  • ( DRUG, NEW_YORK )(1, 1st Order)  top
  • ( DRUG, MERS )(1, 1st Order)  top
  • ( DRUG, IN_CHINA )(1, 1st Order)  top
  • VIRUS(3, 0 Order)
  • ( VIRUS )(3, 0 Order)  top
  • INFLAMMATION(3, 0 Order)
  • ( INFLAMMATION )(3, 0 Order)  top
  • COVID-19(2, 0 Order)
  • ( COVID-19 )(2, 0 Order)  top

    • References

    • ( DRUG )  top
    • ( DRUG, INFLAMMATION )  top
    • (Read more)   top
      A day earlier, Regeneron (ticker: REGN) said it had started trials with its existing arthritis drug, Kevzara, which might prove useful in treating lung inflammation in Covid-19 patients, keeping them off ventilators and out of intensive care units.
      Barron.s spoke with Regeneron CEO Leonard Schleifer on Tuesday morning about the fight against Covid-19, how...
    • (Read more)   topThis may be what.s causing some of the inflammation in the lungs. In China, as this epidemic started, there was a drug made by Roche Holding (ROG.Switzerland), known as Actemra, which blocks the function of the interleukin-6 receptor
    • (Read more)   top[Andrew] Cuomo in New York, and we put in place in record time a clinical trial to see if in fact this approach, blocking the inflammation, might be good.
      On when a drug might be available:
      If the drug is shown to work in hospitalized patients, we have lots of the drug on hand and can make much more
    • ( DRUG, VIRUS )  top
    • (Read more)   top.Similar to the approach the company pursued for Mers and Ebola virus, we believe Regeneron.s Covid-19 antibody cocktail may offer efficacy in preventing and treating the virus,
    • ( DRUG, KEVZARA )  top
    • (Read more)   top
      A day earlier, Regeneron (ticker: REGN) said it had started trials with its existing arthritis drug, Kevzara, which might prove useful in treating lung inflammation in Covid-19 patients, keeping them off ventilators and out of intensive care units.
      Barron.s spoke with Regeneron CEO Leonard Schleifer on...
    • (Read more)   top One is Roche.s drug, and the other is our drug, Kevzara. We worked very rapidly to design a trial. We worked closely with the FDA, collaborated with Barda [Biomedical Advanced Research and Development Authority], got help from Gov
    • ( DRUG, EBOLA )  top
    • (Read more)   top.Similar to the approach the company pursued for Mers and Ebola virus, we believe Regeneron.s Covid-19 antibody cocktail may offer efficacy in preventing and treating the virus,
    • ( DRUG, ANTIBODIES )  top
    • (Read more)   top It has identified hundreds of virus-neutralizing antibodies that could potentially be used in a cocktail drug.
      .Similar to the approach the company pursued for Mers and Ebola virus, we believe Regeneron.s Covid-19 antibody cocktail may offer efficacy in...
    • (Read more)   topThird, get a vaccine so that the body can make these antibodies itself.
      On using existing treatments:
      You can break them into two broad categories
    • ( DRUG, VIRUS-NEUTRALIZING )  top
    • (Read more)   top It has identified hundreds of virus-neutralizing antibodies that could potentially be used in a cocktail drug.
      .Similar to the approach the company pursued for Mers and Ebola virus, we believe Regeneron.s Covid-19 antibody cocktail may offer...
    • ( DRUG, VACCINE )  top
    • (Read more)   topThird, get a vaccine so that the body can make these antibodies itself.
      On using existing treatments:
      You can break them into two broad categories
    • ( DRUG, ROCHE_HOLDING )  top
    • (Read more)   topThis may be what.s causing some of the inflammation in the lungs. In China, as this epidemic started, there was a drug made by Roche Holding (ROG.Switzerland), known as Actemra, which blocks the function of the interleukin-6 receptor
    • ( DRUG, REMDESIVIR )  top
    • (Read more)   top. There are drug trials that I.m aware of with Remdesivir, a Gilead Sciences (GILD) drug, which was tried with Ebola.
    • ( DRUG, NEW_YORK )  top
    • (Read more)   top[Andrew] Cuomo in New York, and we put in place in record time a clinical trial to see if in fact this approach, blocking the inflammation, might be good.
      On when a drug might be available:
      If the drug is shown to...
    • ( DRUG, MERS )  top
    • (Read more)   top.Similar to the approach the company pursued for Mers and Ebola virus, we believe Regeneron.s Covid-19 antibody cocktail may offer efficacy in preventing and treating the virus,
    • ( DRUG, IN_CHINA )  top
    • (Read more)   topThis may be what.s causing some of the inflammation in the lungs. In China, as this epidemic started, there was a drug made by Roche Holding (ROG.Switzerland), known as Actemra, which blocks the function of the interleukin-6 receptor
    • ( VIRUS )  top
    • (Read more)   topThere are drug trials that I.m aware of with Remdesivir, a Gilead Sciences (GILD) drug, which was tried with Ebola. The idea there is you interfere with the functioning of the virus. Another thing you can think about is, are there any drugs that can prevent the virus from wreaking havoc on the body
    • (Read more)   topWhen the virus gets into the lungs, it causes this massive inflammation. Maybe, just maybe, if you control the inflammation, you.ll be able do something to prevent patients from needing a respirator, and make their...
    • (Read more)   top ... economics of developing a Covid-19 treatment: There are some people who suggest we.re sitting around rubbing our hands together trying to figure out how to profit from the misfortune of this virus. This couldn.t be further from the truth. You have people who are risking their health, and that of their families, by coming to work in the labs and manufacturing facilities to do all that stuff with...
    • ( INFLAMMATION )  top
    • (Read more)   top... Geoffrey Porges wrote in a note to investors. A day earlier, Regeneron (ticker: REGN) said it had started trials with its existing arthritis drug, Kevzara, which might prove useful in treating lung inflammation in Covid-19 patients, keeping them off ventilators and out of intensive care units. Barron.s spoke with Regeneron CEO Leonard Schleifer on Tuesday morning about the fight against Covid-19, how...
    • (Read more)   top Its mechanism of action is that we have these inflammatory mediators in the body called cytokines, and one of the bad ones is interleukin-6, which causes lots of inflammation. This may be what.s causing some of the inflammation in the lungs. In China, as this epidemic started, there was a drug made by Roche Holding (ROG.Switzerland), known as Actemra, which blocks the...
    • (Read more)   top[Andrew] Cuomo in New York, and we put in place in record time a clinical trial to see if in fact this approach, blocking the inflammation, might be good. On when a drug might be available: If the drug is shown to work in hospitalized patients, we have lots of the drug on hand and can make much more
    • ( COVID-19 )  top
    • (Read more)   top... in a note to investors. A day earlier, Regeneron (ticker: REGN) said it had started trials with its existing arthritis drug, Kevzara, which might prove useful in treating lung inflammation in Covid-19 patients, keeping them off ventilators and out of intensive care units. Barron.s spoke with Regeneron CEO Leonard Schleifer on Tuesday morning about the fight against Covid-19, how the company.s...
    • (Read more)   topWe have these capabilities end-to-end, so there.s no friction at any transfer point. On the economics of developing a Covid-19 treatment: There are some people who suggest we.re sitting around rubbing our hands together trying to figure out how to profit from the misfortune of this virus