Complex Event Analysis - Report 2020/03/18

Complex Event Analysis - REPORT 2020/03/18

Supporting narratives:

• challenge (Read more)
• It has identified hundreds of virus-neutralizing antibodies that could potentially be used in a cocktail drug.
  .Similar to the approach the company pursued for Mers and Ebola virus, we believe Regeneron.s Covid-19 antibody cocktail may offer efficacy in preventing and treating the virus,
• High Level Abstractions:
• (drug,ebola)
• (drug,virus)
• (drug,virus-neutralizing)
• (antibodies,drug)
• (drug,mers)
• Inferred entity relationships (12)

  (drug,vaccine) [inferred]

  (drug,ebola) [inferred]

  (drug,roche_holding) [inferred]

  (drug,virus) [inferred]

  (drug,in_china) [inferred]

  (drug,kevzara) [inferred]

  (drug,remdesivir) [inferred]

  (virus,world_health_organisation) [inferred]

  (virus,workers) [inferred]

  (drug,mers) [inferred]

  (drug,virus-neutralizing) [inferred]

  (drug,new_york) [inferred]

• challenge (Read more)
• One is Roche.s drug, and the other is our drug, Kevzara. We worked very rapidly to design a trial. We worked closely with the FDA, collaborated with Barda [Biomedical Advanced Research and Development Authority], got help from Gov
• High Level Abstractions:
• (drug,kevzara)
• Inferred entity relationships (9)

  (drug,remdesivir) [inferred]

  (drug,vaccine) [inferred]

  (drug,ebola) [inferred]

  (drug,roche_holding) [inferred]

  (drug,virus) [inferred]

  (drug,in_china) [inferred]

  (drug,mers) [inferred]

  (drug,virus-neutralizing) [inferred]

  (drug,new_york) [inferred]

• challenge (Read more)
• We have these capabilities end-to-end, so there.s no friction at any transfer point.
  On the economics of developing a Covid-19 treatment:
  There are some people who suggest we.re sitting around rubbing our hands together trying to figure out how to profit from the misfortune of this virus. This couldn.t be further from the truth. You have people who are risking their health, and that of their families, by coming to work in the labs and manufacturing facilities to do all that stuff with only one goal in mind: How fast can Regeneron produce this and deliver it to the public
• High Level Abstractions:
• (virus)
• Inferred entity relationships (2)

  (virus,world_health_organisation) [inferred]

  (virus,workers) [inferred]

• WIP (Read more)
• SVB Leerink analyst Geoffrey Porges wrote in a note to investors.
  A day earlier, Regeneron (ticker: REGN) said it had started trials with its existing arthritis drug, Kevzara, which might prove useful in treating lung inflammation in Covid-19 patients, keeping them off ventilators and out of intensive care units.
  Barron.s spoke with Regeneron CEO Leonard Schleifer on Tuesday morning about the fight against Covid-19, how the company.s technology platform is speeding drug discovery, and how to think about the economics of treatments for pandemic diseases
• High Level Abstractions:
• (drug,kevzara)
• (drug,inflammation)
• Inferred entity relationships (10)

  (drug,remdesivir) [inferred]

  (drug,vaccine) [inferred]

  (drug,ebola) [inferred]

  (drug,roche_holding) [inferred]

  (drug,virus) [inferred]

  (drug,in_china) [inferred]

  (drug,mers) [inferred]

  (drug,virus-neutralizing) [inferred]

  (drug,kevzara) [inferred]

  (drug,new_york) [inferred]

• WIP (Read more)
• This may be what.s causing some of the inflammation in the lungs. In China, as this epidemic started, there was a drug made by Roche Holding (ROG.Switzerland), known as Actemra, which blocks the function of the interleukin-6 receptor
• High Level Abstractions:
• (drug,in_china)
• (drug,inflammation)
• (drug,roche_holding)
• Inferred entity relationships (10)

  (drug,vaccine) [inferred]

  (drug,ebola) [inferred]

  (drug,roche_holding) [inferred]

  (drug,virus) [inferred]

  (drug,in_china) [inferred]

  (drug,kevzara) [inferred]

  (drug,remdesivir) [inferred]

  (drug,mers) [inferred]

  (drug,virus-neutralizing) [inferred]

  (drug,new_york) [inferred]

• WIP (Read more)
• [Andrew] Cuomo in New York, and we put in place in record time a clinical trial to see if in fact this approach, blocking the inflammation, might be good.
  On when a drug might be available:
  If the drug is shown to work in hospitalized patients, we have lots of the drug on hand and can make much more
• High Level Abstractions:
• (drug,new_york)
• (drug,inflammation)
• Inferred entity relationships (10)

  (drug,remdesivir) [inferred]

  (drug,vaccine) [inferred]

  (drug,ebola) [inferred]

  (drug,roche_holding) [inferred]

  (drug,virus) [inferred]

  (drug,in_china) [inferred]

  (drug,mers) [inferred]

  (drug,virus-neutralizing) [inferred]

  (drug,kevzara) [inferred]

  (drug,new_york) [inferred]

• WIP (Read more)
• Third, get a vaccine so that the body can make these antibodies itself.
  On using existing treatments:
  You can break them into two broad categories
• High Level Abstractions:
• (antibodies,drug)
• (drug,vaccine)
• Inferred entity relationships (10)

  (drug,vaccine) [inferred]

  (drug,ebola) [inferred]

  (drug,roche_holding) [inferred]

  (drug,virus) [inferred]

  (drug,in_china) [inferred]

  (drug,kevzara) [inferred]

  (drug,remdesivir) [inferred]

  (drug,mers) [inferred]

  (drug,virus-neutralizing) [inferred]

  (drug,new_york) [inferred]

• WIP (Read more)
• Third, get a vaccine so that the body can make these antibodies itself.
  On using existing treatments:
  You can break them into two broad categories. People are looking at antivirals. There are drug trials that I.m aware of with Remdesivir, a Gilead Sciences (GILD) drug, which was tried with Ebola.
• High Level Abstractions:
• (drug,remdesivir)
• Inferred entity relationships (9)

  (drug,vaccine) [inferred]

  (drug,ebola) [inferred]

  (drug,roche_holding) [inferred]

  (drug,virus) [inferred]

  (drug,in_china) [inferred]

  (drug,mers) [inferred]

  (drug,virus-neutralizing) [inferred]

  (drug,kevzara) [inferred]

  (drug,new_york) [inferred]

• WIP (Read more)
• There are drug trials that I.m aware of with Remdesivir, a Gilead Sciences (GILD) drug, which was tried with Ebola. The idea there is you interfere with the functioning of the virus. Another thing you can think about is, are there any drugs that can prevent the virus from wreaking havoc on the body
• High Level Abstractions:
• (virus)
• Inferred entity relationships (2)

  (virus,world_health_organisation) [inferred]

  (virus,workers) [inferred]

• WIP (Read more)
• When the virus gets into the lungs, it causes this massive inflammation. Maybe, just maybe, if you control the inflammation, you.ll be able do something to prevent patients from needing a respirator, and make their fever go away.
  That.s our drug, Kevzara
• High Level Abstractions:
• (virus)
• Inferred entity relationships (2)

  (virus,world_health_organisation) [inferred]

  (virus,workers) [inferred]

Target rule match count: 13.0 Challenge: 0.18 Momentum: 0.00 WIP: 0.32