Complex Event Analysis - Report

Complex Event Analysis - REPORT

Supporting narratives:

• momentum (Read more)
• Moderna reports positive data on early-stage coronavirus vaccine trial, shares surge
  Mderna's closely watched early-stage human trial for a coronavirus vaccine produced Covid-19 antibodies in all 45 participants, the biotech company announced Monday, sending the company's shares surging more than 17%.
  Each participant received a 25, 100 or 250 microgram dose, with 15 people in each dose group
• High Level Abstractions:
• (antibodies,coronavirus,covid-19)
• (covid-19,early-stage)
• (antibodies,covid-19,vaccine)
• (antibodies,coronavirus,vaccine)
• (antibodies,early-stage,vaccine)
• (antibodies,covid-19,early-stage)
• (coronavirus,covid-19,vaccine)
• (coronavirus,vaccine)
• (covid-19,early-stage,vaccine)
• (early-stage,vaccine)
• (coronavirus,covid-19)
• Inferred entity relationships (25)

  (coronavirus,covid-19,vaccine) [inferred]

  (antibodies,coronavirus,covid-19) [inferred]

  (coronavirus,covid-19,drug) [inferred]

  (early-stage,vaccine) [inferred]

  (covid-19,vaccine,wuhan) [inferred]

  (antibodies,coronavirus,vaccine) [inferred]

  (coronavirus,covid-19,moderna) [inferred]

  (coronavirus,covid-19,hong_kong) [inferred]

  (coronavirus,covid-19,drug,kaletra) [inferred]

  (coronavirus,vaccine,white_house) [inferred]

  (antibodies,covid-19,early-stage) [inferred]

  (antibodies,covid-19,micrograms) [inferred]

  (antibodies,covid-19,moderna) [inferred]

  (coronavirus,covid-19,kaletra) [inferred]

  (coronavirus,covid-19,drug,hong_kong) [inferred]

  (covid-19,early-stage,vaccine) [inferred]

  (covid-19,early-stage) [inferred]

  (coronavirus,vaccine) [inferred]

  (antibodies,covid-19,microgram) [inferred]

  (antibodies,covid-19,mrna-1273) [inferred]

  (coronavirus,vaccine,vaccines) [inferred]

  (coronavirus,covid-19) [inferred]

  (antibodies,covid-19,vaccine) [inferred]

  (covid-19,vaccine,zaks) [inferred]

  (coronavirus,covid-19,hong_kong,kaletra) [inferred]

• momentum (Read more)
• Moderna reports positive data on early-stage coronavirus vaccine trial, shares surge
  Mderna's closely watched early-stage human trial for a coronavirus vaccine produced Covid-19 antibodies in all 45 participants, the biotech company announced Monday, sending the company's shares surging more than 17%.
  Each participant received a 25, 100 or 250 microgram dose, with 15 people in each dose group.
• High Level Abstractions:
• (covid-19,microgram)
• (antibodies,covid-19,microgram)
• (antibodies,microgram,vaccine)
• (microgram,vaccine)
• Inferred entity relationships (7)

  (microgram,vaccine) [inferred]

  (antibodies,covid-19,mrna-1273) [inferred]

  (covid-19,microgram) [inferred]

  (antibodies,covid-19,vaccine) [inferred]

  (antibodies,covid-19,early-stage) [inferred]

  (antibodies,covid-19,micrograms) [inferred]

  (antibodies,covid-19,moderna) [inferred]

• challenge (Read more)
• Participants received two doses of the potential vaccine via intramuscular injection in the upper arm approximately 28 days apart.
  At day 43, or two weeks following the second dose, levels of binding antibodies in the 25 microgram group were at the levels generally seen in blood samples from people who recovered from the disease, the company said
• High Level Abstractions:
• (antibodies,microgram,vaccine)
• Inferred entity relationships (1)

  (microgram,vaccine) [inferred]

• WIP (Read more)
• Data on neutralizing antibodies for the other participants were not yet available, Moderna said.
  "These interim Phase 1 data, while early, demonstrate that vaccination with mRNA-1273 elicits an immune response of the magnitude caused by natural infection starting with a dose as low as 25 [micrograms]," Moderna chief medical officer Dr. Tal Zaks said in a statement.
  "When combined with the success in preventing viral replication in the lungs of a pre-clinical challenge model at a dose that elicited similar levels of neutralizing antibodies, these data substantiate our belief that mRNA-1273 has the potential to prevent COVID-19 disease and advance our ability to select a dose for pivotal trials," Zaks added.
  Moderna CEO on the promising preliminary results of early-stage Covid-19 study
  Scientists hope the antibodies provide some degree of protection against getting Covid-19, but they can't say that definitively yet since it hasn't been studied and some patients appear to have been reinfected after recovering from the virus.
  There are no formally approved treatments for Covid-19, which has killed at least 315,225 and sickened 4.7 million people worldwide since emerging from the Chinese city of Wuhan more than four months ago, according to Johns Hopkins University
• High Level Abstractions:
• (covid-19,moderna,vaccine)
• (covid-19,zaks)
• (antibodies,moderna,vaccine)
• (moderna,vaccine)
• (covid-19,mrna-1273,vaccine)
• (covid-19,vaccine,zaks)
• (antibodies,covid-19,vaccine)
• (antibodies,covid-19,moderna)
• (antibodies,covid-19,mrna-1273)
• (covid-19,moderna)
• (antibodies,mrna-1273,vaccine)
• (antibodies,vaccine,zaks)
• (covid-19,early-stage,vaccine)
• (mrna-1273,vaccine)
• Inferred entity relationships (16)

  (covid-19,moderna,vaccine) [inferred]

  (early-stage,vaccine) [inferred]

  (covid-19,vaccine,wuhan) [inferred]

  (covid-19,moderna) [inferred]

  (moderna,vaccine,vaccines,white_house) [inferred]

  (antibodies,covid-19,early-stage) [inferred]

  (antibodies,covid-19,micrograms) [inferred]

  (antibodies,covid-19,moderna) [inferred]

  (moderna,vaccine) [inferred]

  (covid-19,early-stage) [inferred]

  (mrna-1273,vaccine) [inferred]

  (covid-19,mrna-1273,vaccine) [inferred]

  (antibodies,covid-19,microgram) [inferred]

  (antibodies,covid-19,mrna-1273) [inferred]

  (antibodies,covid-19,vaccine) [inferred]

  (covid-19,vaccine,zaks) [inferred]

• WIP (Read more)
• Data on neutralizing antibodies for the other participants were not yet available, Moderna said.
  "These interim Phase 1 data, while early, demonstrate that vaccination with mRNA-1273 elicits an immune response of the magnitude caused by natural infection starting with a dose as low as 25 [micrograms]," Moderna chief medical officer Dr. Tal Zaks said in a statement.
  "When combined with the success in preventing viral replication in the lungs of a pre-clinical challenge model at a dose that elicited similar levels of neutralizing antibodies, these data substantiate our belief that mRNA-1273 has the potential to prevent COVID-19 disease and advance our ability to select a dose for pivotal trials," Zaks added.
  Moderna CEO on the promising preliminary results of early-stage Covid-19 study
  Scientists hope the antibodies provide some degree of protection against getting Covid-19, but they can't say that definitively yet since it hasn't been studied and some patients appear to have been reinfected after recovering from the virus.
  There are no formally approved treatments for Covid-19, which has killed at least 315,225 and sickened 4.7 million people worldwide since emerging from the Chinese city of Wuhan more than four months ago, according to Johns Hopkins University.
• High Level Abstractions:
• (covid-19,vaccine,wuhan)
• Inferred entity relationships (1)

  (covid-19,vaccine,zaks) [inferred]

• WIP (Read more)
• At least eight vaccines are in human trials.
  Moderna, which has been fast-tracking work with the National Institutes of Health to develop a vaccine, is the first company to release data on a human trial testing a coronavirus vaccine.
  The company said it expects to begin a phase 3 trial in July.
  Earlier this month, Moderna announced that it was wrapping up phase one human trials on its potential vaccine with the U.S. government and is moving to start phase two trials that would include 600 participants
• High Level Abstractions:
• (moderna,vaccine)
• (coronavirus,vaccine)
• (vaccine,vaccines)
• Inferred entity relationships (4)

  (vaccine,vaccines,white_house) [inferred]

  (moderna,vaccine,vaccines,white_house) [inferred]

  (coronavirus,vaccine,vaccines) [inferred]

  (coronavirus,vaccine,white_house) [inferred]

• WIP (Read more)
• officials have said producing a vaccine to prevent Covid-19 would take 12 to 18 months at the earliest.
  More than 100 vaccines are under development globally, according to the World Health Organization.
• High Level Abstractions:
• (vaccine,vaccines)
• Inferred entity relationships (1)

  (vaccine,vaccines,white_house) [inferred]

• WIP (Read more)
• Data on a second dose was not available for the 250 microgram group, the company said.
  The vaccine also produced neutralizing antibodies against Covid-19 in at least eight participants, the company said
• High Level Abstractions:
• (covid-19,microgram)
• (antibodies,covid-19,microgram)
• Inferred entity relationships (6)

  (antibodies,covid-19,mrna-1273) [inferred]

  (covid-19,microgram) [inferred]

  (antibodies,covid-19,vaccine) [inferred]

  (antibodies,covid-19,early-stage) [inferred]

  (antibodies,covid-19,micrograms) [inferred]

  (antibodies,covid-19,moderna) [inferred]

• WIP (Read more)
• Experts have said neutralizing antibodies appear to be important in acquiring protection.
  Four participants were assigned to receive a 25 microgram dose, while the other four received 100 micrograms.
• High Level Abstractions:
• (antibodies,covid-19,micrograms)
• Inferred entity relationships (5)

  (antibodies,covid-19,microgram) [inferred]

  (antibodies,covid-19,mrna-1273) [inferred]

  (antibodies,covid-19,vaccine) [inferred]

  (antibodies,covid-19,early-stage) [inferred]

  (antibodies,covid-19,moderna) [inferred]

Target rule match count: 41.0 Challenge: 0.01 Momentum: 0.23 WIP: 0.26