Key Focus

  • Coronavirus mutations affect deadliness of strains, Chinese study finds
    Chinese team finds first hard evidence that mutation can affect how severely virus harms its host
    Most aggressive strains could generate 270 times as much viral load as the least potent type
    Stephen Chen
    Stephen Chen in Beijing
    Published 10:41pm 20 Apr. 2020, scmp..com
    A new study by one of China's top scientists has found the ability of the new coronavirus to mutate has been vastly underestimated and different strains may account for different impacts of the disease in various parts of the world.
    Professor Li Lanjuan and her colleagues from Zhejiang University found within a small pool of patients many mutations not previously reported
  • Li and her colleagues suggested that defining mutations in a region might determine actions to fight the virus.
    "Drug and vaccine development, while urgent, need to take the impact of these accumulating mutations
  • These mutations included changes so rare that scientists had never considered they might occur.
    They also confirmed for the first time with laboratory evidence that certain mutations could create strains deadlier than others.
    "Sars-CoV-2 has acquired mutations capable of substantially changing its pathogenicity," Li and her collaborators wrote in a non-peer reviewed paper released on preprint service medRxiv..org on Sunday.
    Li's study provided the first hard evidence that mutation could affect how severely the virus caused disease or damage in its host.
    Li took an unusual approach to investigate the virus mutation


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High Level Topics

  • MUTATIONS
  • STRAINS
  • VIRUS
  • SCIENTISTS
  • High Level Abstractions

  • MUTATIONS(5, 0 Order)
  • ( MUTATIONS )(5, 0 Order)  top
  • ( MUTATIONS, VIRUS )(3, 1st Order)  top
  • ( MUTATIONS, STRAINS )(3, 1st Order)  top
  • ( MUTATIONS, SCIENTISTS )(2, 1st Order)  top
  • ( MUTATIONS, TRI-NUCLEOTIDE )(1, 1st Order)  top
  • ( MUTATIONS, SERVICE )(1, 1st Order)  top
  • ( MUTATIONS, PREPRINT )(1, 1st Order)  top
  • ( MUTATIONS, PATHOGENICITY )(1, 1st Order)  top
  • ( MUTATIONS, NON-PEER )(1, 1st Order)  top
  • ( MUTATIONS, MEDRXIV )(1, 1st Order)  top
  • ( MUTATIONS, HOSPITALS )(1, 1st Order)  top
  • ( MUTATIONS, HEALTH )(1, 1st Order)  top
  • ( MUTATIONS, DEADLIER )(1, 1st Order)  top
  • STRAINS(4, 0 Order)
  • ( STRAINS )(4, 0 Order)  top
  • VIRUS(5, 0 Order)
  • ( VIRUS )(5, 0 Order)  top
  • ( VIRUS, SCIENTISTS )(3, 1st Order)  top
  • ( VIRUS, ZHANG )(1, 1st Order)  top
  • ( VIRUS, STRAINS )(3, 1st Order)  top
  • ( VIRUS, SERVICE )(1, 1st Order)  top
  • ( VIRUS, SCMP_RESEARCH )(1, 1st Order)  top
  • ( VIRUS, PREPRINT )(1, 1st Order)  top
  • ( VIRUS, PATHOGENICITY )(1, 1st Order)  top
  • ( VIRUS, OVERTURNS )(1, 1st Order)  top
  • ( VIRUS, NON-PEER )(1, 1st Order)  top
  • ( VIRUS, MEDRXIV )(1, 1st Order)  top
  • ( VIRUS, DEADLIER )(1, 1st Order)  top
  • SCIENTISTS(3, 0 Order)
  • ( SCIENTISTS )(3, 0 Order)  top
  • References

    • ( MUTATIONS )  top
    • ( MUTATIONS, VIRUS )  top
    • (Read more)   topCoronavirus mutations affect deadliness of strains, Chinese study finds
      Chinese team finds first hard evidence that mutation can affect how severely virus harms its host
      Most aggressive strains could generate 270 times as much viral load as the least potent type
      Stephen Chen
      Stephen Chen in Beijing
      Published 10:41pm 20 Apr. 2020, scmp..com
      A...
    • (Read more)   top
      Li's study provided the first hard evidence that mutation could affect how severely the virus caused disease or damage in its host.
      Li took an unusual approach to investigate the virus mutation
    • (Read more)   topLi and her colleagues suggested that defining mutations in a region might determine actions to fight the virus.
      "Drug
      and vaccine development, while urgent, need to take the impact of these accumulating mutations
    • ( MUTATIONS, STRAINS )  top
    • (Read more)   topCoronavirus mutations affect deadliness of strains, Chinese study finds
      Chinese team finds first hard evidence that mutation can affect how severely virus harms its host
      Most aggressive strains could generate 270 times as much viral load as...
    • (Read more)   top
      They also confirmed for the first time with laboratory evidence that certain mutations could create strains deadlier than others.
      "Sars-CoV-2 has acquired mutations capable of substantially changing its pathogenicity," Li and her collaborators wrote in a non-peer reviewed paper released on preprint...
    • (Read more)   top
      Genetic scientists had noticed that the dominant strains in different geographic regions were inherently different. Some researchers suspected the varying mortality rates could, in part, be caused by mutations but they had no direct proof.
      The issue was...
    • ( MUTATIONS, SCIENTISTS )  top
    • (Read more)   top
      A new study by one of China's top scientists has found the ability of the new coronavirus to mutate has been vastly underestimated and different strains may account for different impacts of the disease in various parts of the world.
      Professor...
    • (Read more)   topThese mutations included changes so rare that scientists had never considered they might occur.
      They also confirmed for the first time with laboratory evidence that certain mutations could create strains deadlier than others.
      "Sars-CoV-2 has acquired...
    • ( MUTATIONS, TRI-NUCLEOTIDE )  top
    • (Read more)   top
      The researchers also found three consecutive changes - known as tri-nucleotide mutations - in a 60-year-old patient, which was a rare event. Usually the genes mutated at one site at a time
    • ( MUTATIONS, SERVICE )  top
    • (Read more)   top
      "Sars-CoV-2 has acquired mutations capable of substantially changing its pathogenicity," Li and her collaborators wrote in a non-peer reviewed paper released on preprint service medRxiv..org on Sunday.
      Li's study provided the first hard evidence that mutation could affect how severely the virus caused disease or damage in its host.
      Li took an unusual approach to...
    • ( MUTATIONS, PREPRINT )  top
    • (Read more)   top
      "Sars-CoV-2 has acquired mutations capable of substantially changing its pathogenicity," Li and her collaborators wrote in a non-peer reviewed paper released on preprint service medRxiv..org on Sunday.
      Li's study provided the first hard evidence that mutation could affect how severely the virus caused disease or damage in its host.
      Li took an unusual approach...
    • ( MUTATIONS, PATHOGENICITY )  top
    • (Read more)   top
      "Sars-CoV-2 has acquired mutations capable of substantially changing its pathogenicity," Li and her collaborators wrote in a non-peer reviewed paper released on preprint service medRxiv..org on Sunday.
      Li's study provided the first hard evidence that mutation could affect how...
    • ( MUTATIONS, NON-PEER )  top
    • (Read more)   top
      "Sars-CoV-2 has acquired mutations capable of substantially changing its pathogenicity," Li and her collaborators wrote in a non-peer reviewed paper released on preprint service medRxiv..org on Sunday.
      Li's study provided the first hard evidence that mutation could affect how severely the virus caused disease or damage in...
    • ( MUTATIONS, MEDRXIV )  top
    • (Read more)   top
      "Sars-CoV-2 has acquired mutations capable of substantially changing its pathogenicity," Li and her collaborators wrote in a non-peer reviewed paper released on preprint service medRxiv..org on Sunday.
      Li's study provided the first hard evidence that mutation could affect how severely the virus caused disease or damage in its host.
      Li took an unusual approach to investigate the...
    • ( MUTATIONS, HOSPITALS )  top
    • (Read more)   top
      In hospitals, Covid-19 has been treated as one disease and patients have received the same treatment regardless of the strain they have
    • ( MUTATIONS, HEALTH )  top
    • (Read more)   top
      The issue was further complicated because survival rates depended on many factors, such as age, underlying health conditions or even blood type.
      In hospitals, Covid-19 has been treated as one disease and patients have received the same treatment regardless of the strain they have
    • ( MUTATIONS, DEADLIER )  top
    • (Read more)   top
      They also confirmed for the first time with laboratory evidence that certain mutations could create strains deadlier than others.
      "Sars-CoV-2 has acquired mutations capable of substantially changing its pathogenicity," Li and her collaborators wrote in a non-peer reviewed paper released on preprint service...
    • ( STRAINS )  top
    • (Read more)   topCoronavirus mutations affect deadliness of strains, Chinese study finds Chinese team finds first hard evidence that mutation can affect how severely virus harms its host Most aggressive strains could generate 270 times as much viral load...
    • (Read more)   topThese mutations included changes so rare that scientists had never considered they might occur. They also confirmed for the first time with laboratory evidence that certain mutations could create strains deadlier than others. "Sars-CoV-2 has acquired mutations capable of substantially changing its pathogenicity," Li and her collaborators wrote in a non-peer reviewed paper released on preprint...
    • (Read more)   topThe pandemic's infection and death rates vary from one country to another, and many explanations have been proposed. Genetic scientists had noticed that the dominant strains in different geographic regions were inherently different. Some researchers suspected the varying mortality rates could, in part, be caused by mutations but they had no direct proof. The issue was...
    • (Read more)   top This patient spent more than 50 days in hospital, much longer than other Covid-19 patients, and even his faeces were infectious with living viral strains. "Investigating the functional impact of this tri-nucleotide mutation would be highly interesting," Li and colleagues said in the paper. Professor Zhang Xuegong, head of the bioinformatics division at the National Laboratory...
    • ( VIRUS )  top
    • ( VIRUS, SCIENTISTS )  top
    • (Read more)   topSee ( MUTATIONS , SCIENTISTS )
    • (Read more)   topQuestions such as where the virus came from, why it could kill some healthy young people while generating no detectable symptoms in many others still left scientists scratching their heads.
      "If there is a discovery that overturns the prevailing perception, don't be surprised."
      Sign up now and get a 10% discount (original price US$400) off the China AI Report...
    • ( VIRUS, ZHANG )  top
    • (Read more)   top
      "Our understanding of the virus remains quite shallow," Zhang said. Questions such as where the virus came from, why it could kill some healthy young people while generating no detectable symptoms in many others still left scientists scratching their heads.
      "If...
    • ( VIRUS, STRAINS )  top
    • (Read more)   topSee ( MUTATIONS , STRAINS )
    • (Read more)   top This patient spent more than 50 days in hospital, much longer than other Covid-19 patients, and even his faeces were infectious with living viral strains.
      "Investigating
      the functional impact of this tri-nucleotide mutation would be highly interesting," Li and colleagues said in the paper.
      Professor Zhang Xuegong, head of the bioinformatics division at the National Laboratory...
    • ( VIRUS, SERVICE )  top
    • (Read more)   topSee ( MUTATIONS , SERVICE )
    • ( VIRUS, SCMP_RESEARCH )  top
    • (Read more)   top
      Sign up now and get a 10% discount (original price US$400) off the China AI Report 2020 by SCMP Research.
    • ( VIRUS, PREPRINT )  top
    • (Read more)   topSee ( MUTATIONS , PREPRINT )
    • ( VIRUS, PATHOGENICITY )  top
    • (Read more)   topSee ( MUTATIONS , PATHOGENICITY )
    • ( VIRUS, OVERTURNS )  top
    • (Read more)   top
      "If there is a discovery that overturns the prevailing perception, don't be surprised."
      Sign up now and get a 10% discount (original price US$400) off the China AI Report 2020 by SCMP Research
    • ( VIRUS, NON-PEER )  top
    • (Read more)   topSee ( MUTATIONS , NON-PEER )
    • ( VIRUS, MEDRXIV )  top
    • (Read more)   topSee ( MUTATIONS , MEDRXIV )
    • ( VIRUS, DEADLIER )  top
    • (Read more)   topSee ( MUTATIONS , DEADLIER )
    • ( SCIENTISTS )  top
    • (Read more)   top... times as much viral load as the least potent type Stephen Chen Stephen Chen in Beijing Published 10:41pm 20 Apr. 2020, scmp..com A new study by one of China's top scientists has found the ability of the new coronavirus to mutate has been vastly underestimated and different strains may account for different impacts of the disease in various parts of the world. Professor...
    • (Read more)   topThese mutations included changes so rare that scientists had never considered they might occur. They also confirmed for the first time with laboratory evidence that certain mutations could create strains deadlier than others. "Sars-CoV-2 has acquired...
    • (Read more)   topQuestions such as where the virus came from, why it could kill some healthy young people while generating no detectable symptoms in many others still left scientists scratching their heads. "If there is a discovery that overturns the prevailing perception, don't be surprised." Sign up now and get a 10% discount (original price US$400) off the...